St Joseph has acquired a site at Eastside Locks to the east of the City Centre, close to the coming HS2 station and Birmingham's knowledge quarter.
High quality homes for up to 2,000 people are set to be built across these two developments, alongside a mix of new shops, cafes, offices and inviting public spaces.
St Joseph will also develop its new regional head office at the Eastside Locks site. Once complete, the company will move here from its current home in the city.
The announcements follow the recent launch of St Joseph's first Birmingham based development, Snow Hill Wharf, where the first of 404 new homes are now on sale.
Berkeley Group Chairman, Tony Pidgley CBE, said:
"In partnership with Birmingham City Council, we will transform these long vacant sites into thriving communities with the new homes, jobs and amenities local people need.
The council has real commitment and vision to create homes and communities for its people. It's a fantastic city and a great place to do business.
We have ambitious, long term plans for Birmingham and these sites will be followed by many others in the years to come."
Leader of Birmingham City Council, Cllr Ian Ward, said:
"The sheer scale of this major investment from the Berkeley Group is a huge vote of confidence in Birmingham's future and further enhances our growing reputation as the place to invest and to relocate.
The quality developments at Eastside Locks and Snow Hill Wharf are the next exciting chapters in the ongoing transformation of Birmingham city centre - a transformation that is creating jobs and opportunities for people across the city."
Corporate Director Economy, Waheed Nazir, said:
"Birmingham is experiencing an unprecedented scale of investment. The announcement from the Berkeley Group is a major boost for the city's ambitious growth agenda. Not only will this deliver more homes to meet the needs of our growing population it will also help create high quality, attractive environments and places that are aligned to the needs of modern living.
We are delighted that the Berkeley Group have decided to expand their presence in Birmingham which will complement the already active residential market in the city centre. This announcement is a major step forward for the ongoing development of the city and hugely positive."
About Eastside Locks (St Joseph)
This 2.6-acre site will offer a mix of apartments, set above a collection of canal-side bars, cafes, offices and beautifully landscapes public space set around the Birmingham and Fazeley canal and locks. The plans will complement the on-going transformation of the wider Eastside area, which is close to the coming HS2 station and home to three of Birmingham's top university campuses.
About Snow Hill Queensway (St Edward)
This vacant 0.6-acre site will include one of Birmingham's tallest residential building, with a mix of high quality communal facilities and commercial space on the lower floors.